Albright: Route 26 North (at PA Line Route 26 North becomes Route 281). Follow Route 281 North to Markleysburg. At Markleysburg, turn left on Route 40 West. Follow Route 40 West to Farmington, PA. Turn right onto Route 381 North. Go 5 miles to the Ohiopyle State Park (approx. 45 minutes - 30 miles).

Charleston: I-79 North to Morgantown. I-68 East to Bruceton Mills Exit. Make left at exit onto Route 26 North (at PA Line Route 26 North becomes Route 281). Follow Route 281North to Markleysburg. At Markleysburg, turn left on Route 40 West. Follow Route 40 West to Farmington, PA. Turn right onto Route 381 North. Go 5 miles to the Ohiopyle State Park (approx. 3 ½ hours - 196 miles).

Morgantown: Route 119 North to Uniontown, PA. At exit make right onto Route 40 East. Follow Route 40 East to Farmington, PA. Turn left onto Route 381 North. Go 5 miles to the Ohiopyle State Park (approx. 45 minutes - 35 miles)

Wheeling: I-70 East to Washington, PA. Route 40 East to Farmington, PA. Turn left onto 381 North. Go 5 miles to the Ohiopyle State Park (approx. 2 hours - 102 miles)